Frequently Asked Questions: How to Apply Estrogen and Progesterone Topical Creams

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Women's Health

Applying bioidentical hormone creams correctly is essential for maximizing their benefits. Here are some common questions and detailed answers about the application process for estrogen and progesterone topical creams.

Q1: How do I prepare for applying the cream?

A: Start by washing your hands thoroughly with soap and water. Make sure the area of skin where you will apply the cream is clean and dry. Avoid using any lotions or oils on the skin before application, as they can interfere with absorption.

Q2: Where should I apply the cream?

A: For estrogen and progesterone creams, common application sites include:

  • Inner thighs
  • Abdomen
  • upper arms

Choose an area with less hair and where the skin is not irritated or broken. Rotating application sites is also recommended to minimize irritation.

Q3: How much cream should I use?

A: Your healthcare provider will provide specific dosing instructions. Generally, a measured amount—often indicated by the dosage on the applicator—is used. Common amounts range from a pea-sized to a nickel-sized amount, but follow your prescribed dosage closely (usually measured in mL or #of ‘pumps).

Q4: How do I apply the cream?

A: Here’s a step-by-step guide:

  1. Dispense the Cream: Squeeze the prescribed amount of cream onto your fingers or the applicator.
  2. Apply to Skin: Gently rub the cream onto the selected area of skin. Use circular motions to ensure even distribution.
  3. Let It Absorb: Allow the cream to fully absorb into the skin before covering the area with clothing. This usually takes a few minutes.

Q5: When is the best time to apply the cream?

A: Many women find it convenient to apply it in the morning or evening. Consistency is key, so choose a time that fits well into your daily routine. Slightly higher doses of progesterone can cause mental relaxation and support sleep and in those cases you’ll be specifically asked to apply at bedtime.

Q6: How often should I apply the cream?

A: Follow the specific frequency prescribed by your healthcare provider. Some prescriptions will require you to apply the cream daily, while others may apply it a few times a week. Make sure to adhere to the schedule to maintain hormonal balance. You’ll be provided with education regarding frequency of applications and how to moderate your dose based on symptoms.

Q7: What should I do if I miss a dose?

A: If you miss a dose, apply the cream as soon as you remember. However, if it’s almost time for your next dose, skip the missed application and return to your regular schedule. Do not double up to make up for a missed application.

Q8: Are there any precautions I should take?

A: Yes, here are some important precautions:

  • Avoid applying the cream to broken or irritated skin.
  • Keep the cream away from your eyes and mouth.
  • Store the cream in a cool, dry place, away from direct sunlight.
  • If you experience any of the following, report back to your healthcare provider: breast tenderness, headaches/migraines, vaginal bleeding, nausea. Though uncomfortable side effects, these are not uncommon and do not indicate harm. We’d usually lower the medication dose or reduce frequency of applications in such cases.

Q9: How will I know if the cream is working?

A: You should start noticing improvements in your menopausal symptoms over time. This may include reduced hot flashes, improved mood, and better sleep quality. Regular follow-ups with your healthcare provider can help monitor your progress and make any necessary adjustments to your treatment plan. Other expected benefits: improved energy, focus/concentration, reduced urinary symptoms, improved vitality of skin/hair, positive body composition changes and more!

Q10: Who can I contact for further questions?

A: If you have additional questions or concerns about your hormone therapy, don’t hesitate to reach out to your healthcare provider. If you’re under my care, I, Dr. Negin Misaghi ND, am here to assist you with any inquiries regarding your treatment plan.

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