Progesterone, commonly known as a “female hormone,” plays essential roles in men as well. It supports testosterone synthesis, sperm function, brain health, and cardiovascular stability. In the central nervous system, it promotes sleep and reduces stress through its neurosteroid metabolites, benefiting mental health and resilience. Progesterone may also help in managing benign prostatic hypertrophy and prostate cancer by influencing receptor activity.
- Prostate Health: Progesterone has been shown to influence the prostate, where it may counteract some proliferative effects of androgens, possibly reducing the risk of benign prostatic hyperplasia (BPH) and even modulating prostate cancer progression. Studies confirm that progesterone receptors (PRs) are active in prostate tissues, including both epithelial and stromal cells, which can impact cell growth and hormone signaling pathways critical to prostate health. (study links: 1, 2)
- Neuroprotective Effects: Progesterone’s neurosteroid derivatives have been associated with protective effects in the brain, supporting cognitive health, reducing inflammation, and promoting better sleep. This is beneficial for mental clarity and stress resilience in men, especially as they age. Studies also suggest progesterone’s positive effects in neuroprotection after traumatic brain injuries, emphasizing its role in overall brain health.(PLOS,Frontiers)
- Anti-Inflammatory and Immune Support: Progesterone exhibits anti-inflammatory properties that help balance immune responses, which can be critical in reducing chronic inflammation that may affect cardiovascular and overall health. Progesterone also appears to play a role in respiratory function and may help mitigate risks associated with certain lung conditions. Oxford Academic
- Hormone Balance and Androgen Synthesis: As the precursor to other hormones, progesterone helps maintain testosterone balance in men. Studies reveal that progesterone aids in modulating estrogen and testosterone levels, which are essential in sustaining energy, libido, and muscle mass. This hormone interplay supports bone density and metabolic health, which are crucial for long-term vitality in men. Rupa Health, Natural Hormone Therapy MN, BodyLogicMD
Research consistently supports progesterone’s multifaceted role in male health. Though progesterone is not typically supplemented in men, in cases of hormonal imbalance (high estrogen, low progesterone, low testosterone) it may then become a consideration.
See more from a Testosterone Replacement Therapy* user’s perspective: https://www.youtube.com/watch?v=tsmdvBert1c
*Naturopathic Doctors in Ontario do not yet have the ability to prescribe Testosterone, DHEA or Pregnenolone as described in this video. ND scope only includes the following hormones: Estrogen, Progesterone, Thyroid hormones
